Bile Salt Tolerance Simulator

After surviving stomach acid, probiotics face bile salts in the duodenum (pH ~6.5, 0.3% to 0.5% bile concentration), which act as detergents that can lyse bacterial cell membranes.

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This calculator requires JavaScript. General tolerance data: Bifidobacteria often show higher intrinsic bile resistance than Lactobacilli due to structural membrane differences.

Bacterial Genus

Bile Concentration (%)

Physiological fasting concentration is ~0.3%. Post-prandial (after high fat meal) can spike higher.

Estimated 3-Hour Survival

Remaining viable population entering jejunum.